Originator
Survector,Eutherapie,France,1978
Manufacturing Process
6.5 g of 5-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene in 60 ml of
nitromethane and 10.8 g of ethyl 7-aminoheptanoate in 12ml of nitromethane
were mixed at ambient temperature. The reaction was slightly exothermic.
The reaction mixture was left to stand overnight and the solvent was
evaporated in vacuum. The residue was taken up in normal hydrochloric acid
and the resulting precipitate was filtered off.
10.5 g of crude ethyl 7-[dibenzo(a,d)cycloheptadiene-5-yl]aminoheptanoate
hydrochloride were obtained, of which a sample recrystallized from benzene
gave a pure product melting instantaneously at 166°C to 168°C.
The hydrochloride of the crude ester obtained above was added to 25 ml of 2
N hydrochloric acid. The whole was kept under reflux for 2 hours. The
material dissolved and a new hydrochloride then reprecipitated. After cooling,
the hydrochloride of the crude acid was filtered off, washed with iced water
and then recrystallized from distilled water. 5.7 g of 7-
[dibenzo(a,d)cycloheptadienb-yl] aminoheptanoic acid hydrochloride were
obtained, melting instantaneously at 226°C to 230°C.
