Uses
2-Bromobenzyl bromide was used in the synthesis of substituted quinazolines and 1,2,3,4-tetrahydroquinazolines, 2- and 3-substituted indenes, tris-2-bromotribenzylamine3.
Synthesis
In the reaction flask, 15g of toluene was added to 100mL of glacial acetic acid, and then 3g of iron powder was added to the localization catalyst, and 8mL of bromine was slowly added dropwise under the condition of room temperature for about 30min, and then the reaction was carried out at 40 for 5h, and then put into a tungsten lamp at 300W for 5h, and then the reaction was completely monitored by TLC, and the solvent glacial acetic acid was evaporated under vacuum, and a certain amount of concentrate was added to it. A certain amount of sodium hydroxide solution with a mass concentration of 20% was added to the concentrate, the reaction solution was filtered, the filtrate was extracted with dichloromethane for three times, and the organic phases were combined, and the organic phase was then dried with anhydrous sodium sulfate and concentrated to obtain 24g of o-bromobenzyl bromide; 1HNMR (400MHz, CDCl3) : 7.51 (d, J=12.0Hz, 1H), 7.27-7.23 (m, 3H), 4.37 (s). ,2H).
