Uses
6-tert-Butyl-2,3-naphthalenedicarbonitrile is a stain with bioloigcal research applications. Dyes and metabolites.
Definition
ChEBI: 6-tert-butylnaphthalene-2,3-dicarbonitrile is a member of naphthalenes.
Biological Activity
BRD9876 is an inhibitor of the kinesin spindle protein Eg5. It arrests Eg5-mediated microtubule gliding, as well as inhibits Eg5 ATPase activity in the presence of microtubules, in cell-free assays. BRD9876 is cytotoxic to MM.1S stroma-independent multiple myeloma cells (IC50 = 2.2 μM). It induces cell cycle arrest at the G2/M phase in MM.1S cells when used at a concentration of 10 μM.