Chemical Properties
Purple to Brown powder
Uses
Tanshinone I is an extract from Danshen (Radix Salvia miltiorrhizae) and has been used for the treatment of cerebrovascular diseases such as ischemic stroke.
Definition
ChEBI: Tanshinone I is an abietane diterpenoid. It has a role as an anticoronaviral agent.
Biological Activity
Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules. Anti-inflammatory.', 'TanshinoneI is extensively studied for its anticancer properties, it was reported to inhibit cancer cell invasion, metastasis, and migration and is a potent antitumor agent. It also displays antibacterial, neuroprotective, memory-enhancing, and cardioprotective activities.
Cytotoxicity
IC50 (μg/mL): 2.96 (A549), 2.14 (TOV-21G) (Chang et al. 2013)
IC50 (μg/mL): 10.5 (MIAPaCa-2) (Fronzaet al. 2011)
