Brand Name(s) in US
Dicural
Description
Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including
B. fragilis, as well as
Fusobacterium and
Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates
E. coli and
B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
A fluoroquinolone antibacterial structurally related to norfloxacin.
Uses
A quinolone antibacterial compound. Structurally related to norfloxacin
Uses
antibacterial, DNA gyrase inhibitor
References
[1] M B BANSAL H T. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 4: 619-621. DOI:
10.1128/aac.31.4.619[2] H THADEPALLI S K C S V Gollapudi. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.[J]. Antimicrobial Agents and Chemotherapy, 1986, 30 4: 574-576. DOI:
10.1128/aac.30.4.574
