Uses
Caffeic acid-pYEEIE, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain[1].
Biological Activity
Phosphopeptide ligand for the src SH2 domain (IC 50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, N-Acetyl-O-phosphono-L-tyrosyl-L-a-glutamyl-L-a-glutamyl]-L-a-glutamyl-L-isoleucyl]-L-glutamic acid).
References
[1] See-Hyoung Park, et al. Design and characterization of non-phosphopeptide inhibitors for Src family SH2 domains. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2711-4. DOI:
10.1016/s0960-894x(02)00523-1
