N-omega-Hydroxy-nor-L-arginine, diacetate salt

Chemical Properties

Off-white powder

Uses

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Definition

ChEBI: Nomega-hydroxy-nor-l-arginine is a L-alpha-amino acid.

General Description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 μM) and mouse macrophages (IC₅₀ = 50 μM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Biochem/physiol Actions

Primary Targetarginase from rat liver