Uses
3-Chlorobenzoylacetonitrile has been used in the synthesis biologically active 2-amino-3-benzoylthiophenes and pyrrolopyrimidines that are receptor agonist compounds. 3-Chlorobenzoylacetonitrile and other molecules in its class have also been used in the synthesis of 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives as possible anti-tumor treatments.
Synthesis
3-Chlorobenzoylacetonitrile can be synthesized by carbonylation of aryl iodides with Mo(CO)6 in the presence of trimethylsilylacetonitrile and a palladium catalyst.
1
References
[1]Aldeborgh, H., George, K., Howe, M. et al. Analysis of Small Molecule X-Ray Crystal Structures: Chemical Crystallography with Undergraduate Students in a Teaching Laboratory. J Chem Crystallogr 44, 70–81 (2014).
https://doi.org/10.1007/s10870-013-0485-z
