Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from wild chrysanthemum.
Uses
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production[1].
Definition
ChEBI: Handelin is a sesterterpenoid.
in vivo
Handelin (Compound 1; 10-20 mg/kg; oral administration; for 30 mintues; male Sprague-Dawley rats) treatment inhibits acute inflammation in carrageenan-induced paw edema model. The serum level of IL-1β is also inhibited by Handelin in a carrageenan-induced paw edema model [1].
| Animal Model: | Male Sprague-Dawley (SD) rats (150-170 g, 5 weeks old) injected with carrageenan[1] |
| Dosage: | 10 mg/kg, 20 mg/kg |
| Administration: | Oral administration; for 30 mintues |
| Result: | Inhibited acute inflammation in carrageenan-induced paw. The serum level of IL-1β was also inhibited.
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References
[1] Y Pyee, et al. Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production. J Nat Prod. 2014 Apr 25;77(4):917-24. DOI:
10.1021/np4009877
