Anticancer Research
Alkaloids are a class of nitrogenous organic compounds of plant origin that havedistinct physiological actions on humans. Coralyne [(C
22H
22O
4N
+) 5, 6, 7, 8, 13, 13ahexadehydro-8-methyl-2, 3, 10, 11-tetramethoxy berberinium] is a heterocyclic analogof protoberberine alkaloid with antileukaemic activity and relatively high DNA/RNA-binding and intercalative potential compared to other isoquinoline compounds.Kumari et al. (2017) reported that treatment of coralyne in combination with paclitaxel(conventional chemotherapeutic drug) may exhibit synergistic effect on inhibitionof proliferation, migration and induction of apoptosis in MDA-MB-231 TNBCcells. They reported that coralyne (10 μM) in combination with paclitaxel (0.1 μM)effectively inhibits MDA-MB-231 cell proliferation and migration at 48 h time point.Further, the combination altered the gene expression of the apoptotic mediators Baxand Bcl-2 (Kumari et al. 2017). Their study revealed that low doses of coralyne andpaclitaxel showed promising therapeutic potential against TNBC cells.
