LENOGRASTIM

Uses

Antineutropenic; hematopoietic stimulant.

Metabolism

Lenograstim is primarily eliminated by the kidney and neutrophils/neutrophil precursors; the latter presumably involves binding of the growth factor to the G-CSF receptor on the cell surface, internalisation of the growth factor-receptor complexes via endocytosis, and subsequent degradation inside the cells. During chemotherapy induced neutropenia, the clearance of lenograstim is significantly reduced and the concentration of lenograstim is sustained until onset of neutrophil recovery.