Originator
Pro-Diaban,Bayer,W. Germany,1974
Manufacturing Process
There is obtained from 4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]-
benzene-sulfonamide (prepared from 5-methyl-isoxazole-(3)-carboxylic acid
chloride and 4-(β-aminoethyl)benzene-sulfonamide hydrochloride, MP 213° to
214°C in pyridine) and chloroformic acid methyl ester, in a yield of 69%, the
compound N-[[-4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]]-benzenesulfonyl]]-methyl-urethane in the form of colorless crystals of MP 173°C.
From the sulfonyl-urethane described above and N-amino-hexamethyleneimine, there is obtained, in a yield of 70%. the compound 4-[[4-[β-[5-methylisoxazolyl-(3)-carboxamido]-ethyl]-benzene-sulfonyl]]-1,1-hexamethylenesemicarbazide in the form of colorless crystals of MP 189°C.
