ChemicalBook CAS DataBase List 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

Product Name5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
CAS874902-19-9
CBNumberCB7842012
MFC17H17N5O
MW307.35
MDL NumberMFCD08703123
MOL File874902-19-9.mol
MSDS FileSDS

Chemical Properties

Melting point	87-88℃
Boiling point	506.1±53.0 °C(Predicted)
Density	1.21
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
pka	0.01±0.10(Predicted)
form	White to off-white solid.
color	White
Stability	Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
FDA UNII	2WBU91OKM7

Safety

Symbol(GHS)

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

Hazard Codes

Risk Statements

NFPA 704:

	0
2		0

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 10008663	1mg	$93	LY2183240 ≥98%	Buy
Cayman Chemical 10008663	5mg	$252	LY2183240 ≥98%	Buy
Tocris 2452	1	$112	LY2183240 ≥98%(HPLC)	Buy
Tocris 2452	10	$237	LY2183240 ≥98%(HPLC)	Buy
TRC L503140	250mg	$790	LY2183240	Buy

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Chemical Properties,Usage,Production

Description

LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2-4 to be an inhibitor of fatty acid amide hydrolase (FAAH) – IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) – IC50 = 5.3 nM3.

Uses

LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide. Synthetic Cannabinoids

Definition

ChEBI: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide is a member of biphenyls.

Biological Activity

Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

in vivo

LY2183240 (3-30mg/kg; i.p.) dose-dependently attenuates formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms^[1].

Animal Model:	Male Sprague-Dawley rats (Formalin Pain Model)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	I.p.
Result:	Dose-dependently attenuated formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.

References

[1] S A MOORE. Identification of a high-affinity binding site involved in the transport of endocannabinoids.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 49: 17852-17857. DOI:10.1073/pnas.0507470102
[2] GIORGIO ORTAR . Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation[J]. European Journal of Medicinal Chemistry, 2008, 43 1: Pages 62-72. DOI:10.1016/j.ejmech.2007.02.023
[3] JESSICA P. ALEXANDER Benjamin F C. The Putative Endocannabinoid Transport Blocker LY2183240 Is a Potent Inhibitor of FAAH and Several Other Brain Serine Hydrolases[J]. Journal of the American Chemical Society, 2006, 128 30: 9699-9704. DOI:10.1021/ja062999h
[4] AMY K DICKASON-CHESTERFIELD. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.[J]. Cellular and Molecular Neurobiology, 2006, 26 4-6: 407-423. DOI:10.1007/s10571-006-9072-6

Preparation Products And Raw materials

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Supplier

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3386	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Shanghai Quedan biology science and technology co., ltd	+86-13004146052	lnzc@quedan.com.cn	China	1022	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	9951	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8501	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33325	58

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