Hydrazinecarbothioamide, 2-[1-(2-thienyl)ethylidene]-, (2Z)-

Biological Activity

SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1 It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50 = 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50 = 5.33 μM) but not cathepsin B when used at a concentration of 20 μM.

References

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