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Argatroban

Argatroban Structure
Argatroban
  • CAS No.74863-84-6
  • Chemical Name:Argatroban
  • CBNumber:CB7738830
  • Molecular Formula:C23H36N6O5S
  • Formula Weight:508.63
  • MOL File:74863-84-6.mol
Argatroban Property
  • Melting point: :188-1890C
  • Boiling point: :777.2±70.0 °C(Predicted)
  • Density  :1.47±0.1 g/cm3(Predicted)
  • storage temp.  :Store at +4°C
  • form  :White to off-white powder.
  • pka :10.44±0.40(Predicted)
  • CAS DataBase Reference :74863-84-6(CAS DataBase Reference)
  • FDA UNII :IY90U61Z3S
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Argatroban Price More Price(4)
  • Brand: Cayman Chemical
  • Product number: 19639
  • Product name : Argatroban
  • Purity: ≥95%
  • Packaging: 5mg
  • Price: $29
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19639
  • Product name : Argatroban
  • Purity: ≥95%
  • Packaging: 10mg
  • Price: $49
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19639
  • Product name : Argatroban
  • Purity: ≥95%
  • Packaging: 25mg
  • Price: $116
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19639
  • Product name : Argatroban
  • Purity: 
  • Packaging: 50mg
  • Price: $218
  • Updated: 2020/06/24
  • Buy: Buy

Argatroban Chemical Properties,Usage,Production

  • Description Argatroban is a new synthetic antithrombotic agent useful in maintenance anticoagulation them ischemic stroke and disseminated intravascular coagulation. In patients on hemodialysis, argatroban is su enor to heparin, generating a more stable antithrombin effect. Other potential uses include progressing ischemic stroke and disseminated intravascular coagulation.
  • Chemical Properties White to Off-White Crystalline Solid
  • Originator Mitsubishi Kasei; Daiichi (Japan)
  • Uses Synthetic thrombin inhibitor. Antithrombotic.
  • Uses anticoagulant;direct thrombine inhibitor
  • brand name Novastan (Mitsubishi Chemical Corporation, Japan);Slonnon.
  • Pharmacokinetics Argatroban is administered subcutaneously because of the low lipophilicity of the drug. The drug is bound to plasma protein and is metabolized via CYP3A4/5 to the aromatized metabolite and the two hydroxylated metabolites. The M-1 metabolite retains 20 to 30% of the antithrombotic activity. Coadministration of argatroban with inhibitors of CYP3A4 does not appear to produce clinically significant effects. Argatroban is eliminated via biliary secretion into the feces.
  • Clinical Use Argatroban has been approved for the prophylaxis and treatment of thrombosis in patients with HIT (79). Argatroban is a peptidomimetic that binds selectively to the catalytic site of thrombin as a univalent competitive DTI. Argatroban is available as a mixture of 21-R and 21-S diastereomers (64:36), with the S-isomer approximately twice as potent as the R-isomer. The drug is a reversible inhibitor of both free thrombin as well as clot-bound thrombin.
Argatroban Preparation Products And Raw materials
Raw materials
Preparation Products
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74863-84-6, ArgatrobanRelated Search:
  • Argatroban (Mixture of Diastereomers)
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  • MQP
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  • ARG025
  • MQPA
  • Argatroban
  • (2R,4R)-1-[5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
  • (2R)-1-[Nα-(3-Methyl-1,2,3,4-tetrahydroquinoline-8-ylsulfonyl)-L-arginyl]-4α-methylpiperidine-2β-carboxylic acid
  • (2R,4R)-1-[(2S)-5-Guanidino-2-(1,2,3,4-tetrahydro-3-methylquinolin-8-ylsulfonylamino)valeryl]-4-methylpiperidine-2-carboxylic acid
  • MD-805
  • DK-7419
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  • MD-805:OM-805:Novastan:Slonnon
  • (2R,4R)-1-((2S)-5-Guanidino-2-(3-Methyl-1,2,3,4-tetrahydroquinoline-8-sulfonaMido)pentanoyl)-4-Methylpiperidine-2-carboxylic acid
  • Novastan
  • OM 805
  • Slonnon
  • 2-Piperidinecarboxylicacid,1-[(2S)-5-[(aMinoiMinoMethyl)aMino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-Methyl-8-quinolinyl)sulfonyl]aMino]pentyl]-4-Methyl-,(2R,4R)-
  • Argatraban
  • (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-
  • Argatroban
  • Ar atroban
  • 74863-84-6
  • C23H36N6O5S
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