Synthesis
In a nitrogen atmosphere, one PTFE magnet was placed in a reactor, and 0.4 mmol p-methylbenzene diazonium tetrafluoroborate, 0.1 mmol cuprous oxide, 1 , 0.8 mmol dimethyl sulfoxide, and finally 1.2 mmol ethyl trifluoropyruvate were added.
mL of dichloromethane, 0.8 mmol of dimethyl sulfoxide, and finally 1.2 mmol of ethyl trifluoropyruvate were added, and the reaction was stirred at 25 C for 16 in a closed system.
After h, the reaction was extracted with ether 3 times, 10 mL each time, the organic phases were combined and washed with distilled water 3 times, the organic phase was dried with anhydrous magnesium sulfate, filtered, and then rotary evaporated to remove the organic solvent .
The obtained crude product was eluted by silica gel column chromatography with n-pentane as eluent to obtain 4-(trifluoroacetyl)toluene (86% isolated yield).
