Description
SNC 80 is a selective nonpeptide agonist of the δ-
opioid receptor (K
i = 0.18 nM, IC
50 = 2.73 nM) that is over 2,000-
fold less effective at the μ-
opioid receptor. It effectively activates μ/δ receptor heteromers (EC
50 = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-
convulsant effects
in vivo.
Chemical Properties
Crystalline Solid
Uses
Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.
5
Uses
A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors
Definition
ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.
Biological Activity
A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors.
Biochem/physiol Actions
SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4
