Chemical Properties
white to light yellow crystal powde
Uses
3-Fluorophenylhydrazine Hydrochloride can be used to synthesize compounds that are useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions.
Synthesis
4) Saltation reaction: 22.1 g of (3-fluorophenyl)hydrazine was dissolved in 15.4 mL of 37% hydrochloric acid and stirred at 65 °C until crystals precipitated from the reaction solution. The reaction solution was then cooled to 20 °C and the solid product was collected by filtration. The filter cake was washed with acetone and dried to give 24.4 g of 3-fluorophenylhydrazine hydrochloride with 99.2% purity and 39.1% yield.
References
[1] Patent: CN106518716, 2017, A. Location in patent: Paragraph 0026
