Synthesis
A method for the preparation of 2-bromo-4-tert-butylphenol, comprising the steps of S11. dissolving 1 mol 4-tert-butylphenol in 300-500 ml of acetic acid solution at room temperature, followed by adding 150-250 ml of water, stirring well, and then adding 1.01 mol of sodium bromide; S12. slowly dropping in 10% sodium chlorite solution (effective chlorine content of 128.2.0 sodium bromide equivalents) over a period of 1-2 hours at room temperature and stirring; and continuing the reaction for 4-8 hours after dropping. Sodium solution (effective chlorine content of 128.2.0 sodium bromide equivalent), after dropping, continue to stir the reaction at room temperature for 4-8 hours. The conversion of 2-bromo-4-tert-butylphenol prepared by this method was more than 99%, the yield was 97% and the purity of the product was 98.3%.
References
[1] Journal of the American Chemical Society, 1982, vol. 104, # 5, p. 1362 - 1368
[2] Chemistry - A European Journal, 2012, vol. 18, # 11, p. 3286 - 3291
[3] Patent: US2014/135320, 2014, A1. Location in patent: Page/Page column 0219
[4] Patent: US2014/135360, 2014, A1. Location in patent: Paragraph 0147
[5] Tetrahedron Asymmetry, 1999, vol. 10, # 3, p. 411 - 427
