2',3'-O-Isopropylideneguanosine

Chemical Properties

White Crystalline Solid

Uses

2',3'-O-Isopropylideneguanosine is a useful precursor for the preparation of nucleic acids

Uses

A useful precursor for the preparation of nucleic acids.

Synthesis

Add 10 mL of anhydrous pyridine to 2 g (7.45 mmol) of solid 2',3'-O-Isopropylideneguanosine to form a white suspension.
1 Remove the pyridine under reduced pressure to remove any trapped water;
2 Repeat the previous step;
3 Add 5 mL of acetone to the residue and stir for 30 minutes;
4 Add 50 mL of ether to the mixture and stir for 1 hour;
5 Filter the resulting precipitate and wash it with ether;
6 Dry the product in a vacuum desiccator over P2O5.

References

[1] RSC Advances, 2018, vol. 8, # 57, p. 32775 - 32793
[2] Synlett, 2010, # 19, p. 2959 - 2963
[3] Patent: WO2006/130161, 2006, A2. Location in patent: Page/Page column 29
[4] Chemistry - A European Journal, 2013, vol. 19, # 35, p. 11502 - 11506
[5] Chemistry - A European Journal, 2014, vol. 20, # 11, p. 3023 - 3028