Biological Activity
Tiludronate is a bisphosphonate bone resorption inhibitor. Tiludronate inhibits protein-tyrosine-phosphatase, leading to detachment of osteoclasts from the bone surface. It also inhibits the osteoclastic proton pump and is used to tre at Pagetμs disease.
Veterinary Drugs and Treatments
Tiludronate disodium (tiludronic acid) is a bisphosphonate bone
resorption inhibitor that is available in some countries for the intravenous
treatment of navicular disease in horses. Treatment earlier
in the course of the disease apparently results in greater efficacy.
For humans, there is an orally administered FDA-approved
product for treating Paget’s disease (osteitis deformans).
