Uses
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome[1].
References
[1] Walter E Kaufmann, et al. ANAVEX2-73 (Blarcamesine), a Sigma-1 Receptor Agonist, Ameliorates Neurologic Impairments in a Mouse Model of Rett Syndrome. Pharmacol Biochem Behav . 2019 Dec;187:172796. DOI:
10.1016/j.pbb.2019.172796[2] VALENTINE LAHMY. Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer’s disease model.[J]. Frontiers in Cellular Neuroscience, 2015: 463. DOI:
10.3389/fncel.2014.00463[3] VALENTINE LAHMY. Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease[J]. Neuropsychopharmacology, 2013, 38 9: 1706-1723. DOI:
10.1038/npp.2013.70
