Description
Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases. Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most commonly leading to excretion in urine and bile.
Chemical Properties
White to Off-White Solid
Uses
A 17β-Estradiol (E888000) metabolite.
References
[1] R RAFTOGIANIS. Estrogen metabolism by conjugation.[J]. Journal of the National Cancer Institute. Monographs, 2000, 27: 113-124. DOI:
10.1093/oxfordjournals.jncimonographs.a024234[2] D W LOE. ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.[J]. The Journal of Biological Chemistry, 1996, 271 16: 9683-9689. DOI:
10.1074/jbc.271.16.9683
