Synthesis
The general procedure for the synthesis of 6-fluoropyridazin-3-amine from 3,6-difluoropyridazine was as follows: 3,6-difluoropyridazine (60.3 mmol) was mixed with 25 mL of ammonia in a sealed reaction tube and reacted at 70 °C for 2 hours. After completion of the reaction, it was cooled to room temperature and the precipitate was collected by filtration. Subsequently, the precipitate was washed with water and dried to give 6-fluoropyridazin-3-amine in a yield of 4.28 g. The reaction was carried out in a sealed reaction tube.
References
[1] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809
[2] Patent: US5049558, 1991, A
[3] ACS Medicinal Chemistry Letters, 2010, vol. 1, # 2, p. 80 - 84
[4] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0582-0584
[5] Patent: CN103130791, 2016, B. Location in patent: Paragraph 0406-0408
