2-[(3-chlorophenyl)Methyl]-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Synthesis

Example 5: Magnesium chips (16.8 mg, 0.7 mmol) were added to the reaction system as an activator under argon protection. Catalyst Fe(acac)3 (3.5 mg, 0.010 mmol, 2 mol%), p-chlorobenzyl chloride (157 μl, 1.35 mmol) and bis(pinacolato)borate (127.0 mg, 0.5 mmol) were added sequentially to tetrahydrofuran (1 ml). The reaction was carried out at -10 °C for 5 h, followed by addition of water to terminate the reaction. The reaction mixture was extracted with ethyl acetate and the product was analyzed by gas chromatography in 81% yield.

References

[1] Chemistry Letters, 2002, # 8, p. 780 - 781
[2] Patent: CN107903281, 2018, A. Location in patent: Paragraph 0026
[3] Journal of the American Chemical Society, 2012, vol. 134, # 25, p. 10693 - 10697
[4] Journal of the American Chemical Society, 2014, vol. 136, # 27, p. 9521 - 9523