Description
Avenanthramide-
C methyl ester is an inhibitor of NF-
κB activation that acts by blocking the phosphorylation of IKK and IκB (IC
50 ~ 40 μM).
1 Through this mechanism, avenanthramide-
C methyl ester dose dependently inhibits the expression and secretion of IL-
6, IL-
8, and MCP-
1 in human aortic endothelial cells.
1
References
1. Guo, W., Wise, M.L., Collins, F.W., et al.
Avenanthramides, polyphenols from oats, inhibit IL-1β-induced NF-κB activation in endothelial cells Free Radic. Biol. Med. 44(3),415-429(2008).
