955382-52-2

Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC₅₀ ~ 40 μM).¹ Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells. ¹

1. Guo, W., Wise, M.L., Collins, F.W., et al. Avenanthramides, polyphenols from oats, inhibit IL-1β-induced NF-κB activation in endothelial cells Free Radic. Biol. Med. 44(3),415-429(2008).