Description
Deoxyribonucleic acid (also known as Deoxyribonucleic acids, fish sperm), abbreviated as PDRN, is a bioactive nucleotide compound extracted from salmon semen. It possesses powerful tissue-repairing and anti-inflammatory properties, promoting cell regeneration and collagen synthesis while improving skin texture and reducing fine lines. It is widely used in skincare, aesthetic medicine, and wound care products.
Chemical Properties
White to off white fibers
Uses
Various concentrations of Deoxyribonucleic acid, low molecular weight, from salmon sperm has been used:
- to study DNA binding to silicon-substituted hydroxyapatite nanocrystals.
- in simple electrochemical DNA biosensors to detect and evaluate DNA damage caused by UV-C radiation and reactive oxygen species.
- as a precursor in the synthesis of the bio-dots.
Application
Deoxyribonucleic acid derived from salmon sperm, as a biological raw material, can be used for:
(1) Drug development: As a low-cost alternative to defibrotide for the treatment of vascular diseases, ischemia, inflammation, thrombosis, and other conditions;
(2) Mechanism research: To study the regulatory mechanisms of the fibrinolytic system, endothelial cell function, and aptamer screening;
(3) Disease treatment: Its fibrinolytic and antithrombotic effects contribute to the substance’s potential value in treating conditions such as deep vein thrombosis and hepatic veno-occlusive disease [1].
Biological Activity
Salmon sperm DNA is often used as a blocking agent invarious research applications. It isknown to improve the specificity and sensitivity of the multi-AP assay byreducing non-specific binding and background signal.
References
[1] Hui, C.-Y., Guo, Y., Zhang, X., Shao, J.-H., Yang, X.-Q., Zhang, W. (2013). Oligodeoxyribonucleotides derived from salmon sperm DNA: An alternative to defibrotide.
Biologicals,
41 3, Pages 190-196.
https://doi.org/10.1016/j.biologicals.2012.12.003
