Description
20-
hydroxy Prostaglandin E
2 (20-
hydroxy PGE
2) is a product of cytochrome P450 metabolism of PGE
2 .
1,2 ω-
Oxidation at C-
20 followed by β-
oxidation and the loss of up to four carbons from the lower side chain is a prominent metabolic pathway for PGE
2. 20-
hydroxy PGE
2 is the putative first intermediate in this chain of chemical transformations.
Definition
ChEBI: 20-hydroxyprostaglandin E2 is a prostaglandin E derivative that is prostaglandin E2 in which one of the methyl hydrogens at position 20 has been replaced by a hydroxy group. It is a prostaglandins E, a secondary allylic alcohol, a primary alcohol and a triol. It is functionally related to a prostaglandin E2. It is a conjugate acid of a 20-hydroxyprostaglandin E2(1-).
References
1. Oliw, E.H.
Observations on the substrate specificity of prostaglandin hydroxylases of monkey seminal vesicles and sheep vesicular glands Biochim. Biophys. Acta 1001,107-110(1989).
2. Oliw, E.H., Fahlstadius, P., and Hamberg, M.
Isolation and biosynthesis of 20-hydroxyprostaglandins E1 and E2 in ram seminal fluid J. Biol. Chem. 261,9216-9221(1986).
