Chemical Properties
light yellow to beige fine crystalline powder
Uses
thiadiazole pharmaceutical intermediate
Uses
In the case of reagents containing several potential donor atoms, one of the first
steps in the study of complex formation is the specification of the functional groups
which actually participate in the complexation reaction. The literature on rhodanine
derivatives provides a good example of such examinations.
Uses
In the synthesis of phenylalanine.
Definition
ChEBI: Rhodanine is a thiazolidinone.
General Description
Light yellow crystals. Density 0.868 g / cm3. Melting point 168.5°C. May explode on rapid heating.
Air & Water Reactions
Water soluble.
Reactivity Profile
Rhodanine may generate hydrogen sulfide with acids. May generate heat and hydrogen gas with alkali metals, nitrides, hydrides, and other strong reducing agents.
Hazard
May explode when heated to 166C. Toxic
by ingestion.
Biochem/physiol Actions
Rhodanine inhibits the multiplication of echovirus 12 and the development of virus-induced morphologic changes.
Purification Methods
Crystallise rhodanine from glacial acetic acid or water. It is used to estimate Ag and gallic acid [Thies & Fischer Microchimica Acta 809 1973]. [Beilstein 27 H 242, 27 I 309, 27 II 288, 27 III/IV 3188.]
