Originator
Magnipen ,Clin-Comar-Byla ,Italy ,1969
Manufacturing Process
0.01 mol of 6-[D(-)α-(aminophenylacetamido)]-penicillanic acid was
suspended in 150 cc of water cooled to +5°C and treated with 0.01 mol of
sodium bicarbonate.
The solution was treated with 0.01 mol of formaldehyde in aqueous solution,
with agitation. The solution was then filtered to eliminate traces of insoluble
product and the filtrate was lyophilized. Sodium 6-[D(-)-alpha-(methyleneamino-phenylacetamido)]-penicillanate was obtained.
