Description
L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared.1 The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.2,3WARNING This product is not for human or veterinary use.
References
[1] O W GRIFFITH R G K. Nitric oxide synthase inhibitors: amino acids.[J]. Methods in enzymology, 1996, 268: 375-392. DOI:
10.1016/s0076-6879(96)68040-9[2] C FREY. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases.[J]. The Journal of Biological Chemistry, 1994, 269 42: 26083-26091.
[3] GARVEY E.P. Purification and Characterization of the Constitutive Nitric-Oxide Synthase from Human Placenta[J]. Archives of biochemistry and biophysics, 1994, 311 2: Pages 235-241. DOI:
10.1006/abbi.1994.1232[4] YAKOV Y. WOLDMAN . Direct chemiluminescence detection of nitric oxide in aqueous solutions using the natural nitric oxide target soluble guanylyl cyclase[J]. Free Radical Biology and Medicine, 2009, 47 10: Pages 1339-1345. DOI:
10.1016/j.freeradbiomed.2009.09.007
