(S)-2-Chloromandelic acid

Chemical Properties

Uses

Synthesis

74-90-8

89-98-5

10421-85-9

52923-20-3

First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under constant stirring, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex of Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The dark green homogeneous solution formed was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) and was 98%; the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%.

References