Description
Bovine myeloid antimicrobial peptide (BMAP) 28 is a synthetic antimicrobial peptide that corresponds to amino acids 132-158 of bovine cathelicidin-5.1 It is active against the bacteria E. coli, S. aureus, methicillin-resistant S. aureus (MRSA), and S. epidermidis and the fungus C. albicans (MICs = 2, 2, 4, 1, and 8 µM, respectively). BMAP 28 induces inner membrane permeabilization in E. coli when used at a concentration of 200 nM. It reduces viral replication of herpes simplex virus 1 (HSV-1) in Vero 76-infected cells when used at a concentration of 5 µM.2 It induces hemolysis of isolated human erythrocytes and is cytotoxic to isolated human neutrophils when used at a concentration of 30 µM.1 BMAP 28 (0.8 mg/kg) increases survival in E. coli- or MRSA-infected mice but not P. aeruginosa-infected mice.2WARNING This product is not for human or veterinary use.
References
[1] B SKERLAVAJ. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.[J]. The Journal of Biological Chemistry, 1996, 271 45: 28375-28381. DOI:
10.1074/jbc.271.45.28375[2] MONICA BENINCASA . In vitro and in vivo antimicrobial activity of two α-helical cathelicidin peptides and of their synthetic analogs[J]. Peptides, 2003, 24 11: Pages 1723-1731. DOI:
10.1016/j.peptides.2003.07.025
