Description
Magainin 2 is a cationic peptide originally isolated from the skin of the African clawed frog (X. laevis) with roles in host defense and antimicrobial activity.1 It is active against the bacteria E. coli, K. pneumoniae, S. epidermidis, S. aureus, and the fungus C. albicans (MICs = 5, 10, 10, 50, and 80 µg/ml, respectively). Magainin 2 (20 µM) reduces germination percentage and mean tube elongation in kiwi fruit pollen.2 It decreases viral replication in Vero cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 (EC50s = 22.16 and 19.8 µM, respectively) without affecting cell viability with a 50% cytotoxic concentration value (CC50) of greater than 100 µM.3WARNING This product is not for human or veterinary use.
References
[1] ZASLOFF M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 15: 5449-5453. DOI:
10.1073/pnas.84.15.5449[2] A. M. SPERANZA E. O A R Taddei. In Vitro Toxicity towards Kiwifruit Pollen of the Antimicrobial Peptides Magainins 1 and 2[J]. Plant Biology, 2008, 9 6: 800-806. DOI:
10.1055/s-2007-965119[3] VANESA C ALBIOL MATANIC Viviana C. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus[J]. International Journal of Antimicrobial Agents, 2004, 23 4: Pages 382-389. DOI:
10.1016/j.ijantimicag.2003.07.022
