Description
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is a highly selective MMP-12 FRET substrate with a kcat/Km value of 1.85·105 M-1s-1. It is a poor substrate of other MMPs with the exception of MMP-13 (kcat/Km = 0.53·105 M-1s-1) and MMP-9 (kcat/Km = 0.33·105 M-1s-1).
Uses
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*105 M-1s-1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*105 M-1s-1) and MMP9 (0.33*105 M-1s-1)[1].
References
[1] Sarah Bregant, et al. Detection of matrix metalloproteinase active forms in complex proteomes: evaluation of affinity versus photoaffinity capture. J Proteome Res. 2009 May;8(5):2484-94. DOI:
10.1021/pr801069c
Sequene
Mca-PLGLEEA-Dpa-NH2
