Uses
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxacyclopentaborane-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester is an intermediate in organic synthesis and pharmaceutical research and development, and can be used in laboratory organic synthesis processes.
Application
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxacyclopentaborane-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester is mainly used as a pharmaceutical intermediate.
Synthesis
Synthesis of tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate from 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine and 1-4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane), which can also be obtained by purification and isolation from tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate.
or![tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate](/NewsImg/2023-11-07/6383495204143117159572989.png)
References
[1] Patent: WO2014/193647, 2014, A2. Location in patent: Paragraph 0185
[2] Patent: CN104119331, 2018, B. Location in patent: Paragraph 0382; 0390; 0391
[3] Patent: WO2010/68292, 2010, A1. Location in patent: Page/Page column 85-86
[4] Patent: WO2014/89280, 2014, A1. Location in patent: Page/Page column 50
[5] Patent: CN103833753, 2017, B. Location in patent: Paragraph 0352; 0358; 0359