3,6-Dibromothieno[3,2-b]thiophene

Uses

3,6-Dibromothiophene[3,2-B]thiophene is used as a pharmaceutical and electronic intermediate.

Application

3,6-Dibromothiophene[3,2-B]thiophene is an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development and chemical and pharmaceutical synthesis processes.

Synthesis

The general procedure for the synthesis of 3,6-dibromothieno[3,2-b]thiophene from tetrabromothieno[3,2-B]thiophene was carried out as follows: tetrabromothieno[3,2-B]thiophene (9.12 g, 20 mmol), acetic acid (500 ml), and toluene (200 ml) were added to the reactor, followed by zinc powder (2.62 g, 40 mmol). The reaction mixture was filtered and the filtrate was concentrated to give the intermediate 3,6-dibromothieno[3,2-b]thiophene (5.36 g, 90% yield). After completion of the reaction, the synthesis of intermediate C-28-2 was carried out.

References

[1] Patent: CN107056798, 2017, A. Location in patent: Paragraph 0065; 0066; 0067
[2] Patent: WO2016/92065, 2016, A1. Location in patent: Page/Page column 21; 22
[3] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 22, p. 3465 - 3470
[4] Patent: CN103172646, 2016, B. Location in patent: Paragraph 0114-0116
[5] Chemical Communications, 2005, # 9, p. 1161 - 1163