SR 31747
- Product NameSR 31747
- CAS132173-07-0
- CBNumberCB71011640
- MW0
- MOL File132173-07-0.mol
- MSDS FileSDS
SR 31747 Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0007776 | 5mg | $314 | SR-31747 99.66% |
Buy |
| ChemScene CS-0007776 | 10mg | $498 | SR-31747 99.66% |
Buy |
| ChemScene CS-0007776 | 50mg | $1462 | SR-31747 99.66% |
Buy |
| ChemScene CS-0007776 | 100mg | $2004 | SR-31747 99.66% |
Buy |
| aablocks AA009AM8 | 5mg | $358 | SR-31747 >98% |
Buy |
SR 31747 Chemical Properties,Usage,Production
Uses
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].in vivo
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1].
References
[1] Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. PMID:7815336[2] Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. DOI:10.1128/MCB.16.6.2719
Preparation Products And Raw materials
SR 31747 Supplier
Global(25)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 | |
| +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29626 | 60 | |
| +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 | |
| 18818260767 | sales@chemegen.com | China | 11123 | 58 | |
| 88888888888 | hongquchem@qq.com | China | 5123 | 58 | |
| +86-13912903754 13912903754 |
info@becaspharma.com | China | 3978 | 58 | |
| 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 | |
| 0531-88924771 15614660963 |
elsa.hang@strongerscience.com | China | 10622 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
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