Description
L-
759,633 is a high-
affinity peripheral cannabinoid receptor (CB
2)-
selective agonist with K
i values of 6.4 and 1,043 nM for CB
2 and central cannabinoid (CB
1) receptors, respectively. L-
759,633 inhibits forskolin-
stimulated cyclic AMP production in CHO cells transfected with CB
2 or CB
1 receptors with IC
50 values of 8.1 nM and 10 μM, respectively.
Uses
L 759633 is a cannabinoid receptor (CB2) selective agonist and a structural analogues of ??9-Tetrahydro Cannabinol, an active constituent of cannabis. L 759633 has analgesic and anti-inflammatory properties.
Definition
ChEBI: 6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)- is a 1-benzopyran.
Biological Activity
High affinity, selective CB 2 receptor agonist (K i values are 6.4 and 1043 nM for CB 2 and CB 1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB 2 receptors expressed in CHO cells (EC 50 = 8.1 nM).
