Uses
2-Propynal is hypothesized to be a possible metabolite of pargyline, a monoamine oxidase inhibitor that is used as an antihypertensive agent. 2-Propynal is also known to induce hepatocyte toxicity in vivo in rats.
Definition
ChEBI: Prop-2-ynal is a ynal and a terminal acetylenic compound. It has a role as a mouse metabolite.
Synthesis Reference(s)
1. Sauer, J. C. OSC 1962, 4, 813.
2. See also: Ghelfi, F.; Grandi, R.; Pagnoni, U. M. SC 1992, 22, 1845.
Synthesis
Propynal is most simply synthesized by oxidation of Propargyl Alcohol.
1,2
Enzyme inhibitor
This aldehyde (FW = 54.048 g/mol; CAS 624-67-9), also known as propynal, synthesized from propargyl alcohol, is an irreversible inhibitor of aldehyde dehydrogenases.
storage
It is recommended that handling of propynal should include the use of a nonglass container and dilution with a sufficient volume of an inert solvent to absorb the heat of polymerization without boiling, e.g. <=10% in toluene. Use in a fume hood.
