Chemical Properties
N-phenylthiourea is a colorless crystalline solid.
Chemical Properties
white crystalline powder
Uses
In medical genetics.
Uses
1-Phenylthiourea is used as a reactant in the preparation of disubstituted thiazoles as potential antibacterial and antiinflammatory agents via condensation of phenacyl bromide with thioureas and thiosemicarbazones.
Definition
ChEBI: N-phenylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor. It is functionally related to a thiourea.
General Description
Needle-like crystals. Used in the manufacture of rodenticides and in medical genetics.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
1-PHENYL-2-THIOUREA is incompatible with strong oxidizers, strong acids and strong bases. 1-PHENYL-2-THIOUREA emits toxic fumes on contact with acid fumes.
Health Hazard
1-PHENYL-2-THIOUREA is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.
Fire Hazard
Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Potential Exposure
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with acids or acid fumes produces toxic fumes of sulfur oxide.
Purification Methods
Crystallise the thiourea from water and dry it at 100o in air. [Beilstein 12 IV 804.]
Incompatibilities
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 2448 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Waste Disposal
In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
