Preparation
Mercuric pyridine-2,3-dicarboxylate was decarboxylated in hot Me₂SO₄ or HMPA to give a mixture of I (major product) and II ( ). I and II (RR1= bond) react with Cl⁻ or I⁻ to give a mixture. (R = Cl, iodo; R1 = h). Tribromide ions I and II (RR1= bond) give I, II (R = Br, R1 = H), and then iodide ions in hot HOAc, I and II (RR1= bond) give bis(carboxypyridyl)mercuric III (X = H + HgI₃⁻). The solution of III (X = electron pair) is deposited in Me₂SO₄. The pyridine-2,3-dicarboxylate ions react with Hg(OAc)₂ in boiling aq. HOAc solution at pH 5.0–5.8 to give MeCO₂HgCH₂CO₂H as the sole organometallic product, which is purified by silica gel column chromatography to give 3-BROMOPYRIDINE-2-CARBOXYLIC ACID.
Application
Due to the excellent coordination ability of 3-bromo-2-pyridinecarboxylic acid organic ligands, research on the self-assembly of these bifunctional ligands with metals to form complexes has been frequently reported. Firstly, researchers have achieved the goal of controlling the properties of complexes by controlling the structure of both the 3-bromo-2-pyridinecarboxylic acid ligands and the complexes through preliminary structural design. Secondly, in the process of constructing complexes using 3-bromo-2-pyridinecarboxylic acid ligands, the introduction of substituents with different electronic effects through structural modification has a significant impact on the framework structure and properties of the complexes. Therefore, charge compensation during the self-assembly process needs to be considered when designing and constructing MOFs. Currently, complexes constructed from 3-bromo-2-pyridinecarboxylic acid ligands are widely used in fields such as fluorescence sensing, gas adsorption/separation, magnetism, and catalysis.
