Description
Thiobutabarbital sodium ,
the sodium salt of 5-sec-butyl-5-ethylthiobarbituric
acid, is a yellowishwhite
amorphous powder soluble in water and
alcohol. The colorless crystals of the free acid melt at 163 – 165 ?C. Thiobutabarbital
is prepared from thiourea and a malonic
ester .
Uses
Inactin
? hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).
General Description
Crystals.
Air & Water Reactions
Slight hygroscopic. Water soluble.
Reactivity Profile
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
Flash point data for INACTIN are not available. INACTIN is probably combustible.
Biochem/physiol Actions
Inactin? is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.
Clinical Use
It is a short-acting intravenous anesthetic. It is
the least potent of the thiobarbiturates and therefore
causes the least number of complications
during anesthesia. The compound is available
as 5 % and 10 % solutions.
