MN(III) PROTOPORPHYRIN IX CHLORIDE

Uses

Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.

References

[1] Cable, et al. Differential effects of metalloporphyrins on messenger RNA levels of δ-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94(2), 649-654 (1994).
[2] DIPANJAN PAN. Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular Targets[J]. Journal of the American Chemical Society, 2008, 130 29: 9186-9187. DOI: 10.1021/ja801482d
[3] RYABOVA E S, NORDLANDER E. Synthesis and reactivity studies of a manganese ‘microperoxidase’ containing b-type heme†[J]. Dalton Transactions, 2005, 7. DOI: 10.1039/b417331g