Uses
Novel inhibitor of tubulin polymerization
Definition
ChEBI: (5-methoxy-1H-indol-2-yl)-phenylmethanone is a N-acylindole.
Biological Activity
Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC 50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo .
References
1. beckers t, reissmann t, schmidt m et al. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. cancer res. 2002 jun 1;62(11):3113-9.
