Piribedil hydrochloride
- Product NamePiribedil hydrochloride
- CAS78213-63-5
- CBNumberCB6338079
- MFC16H19ClN4O2
- MW334.8
- MDL NumberMFCD01689349
- MOL File78213-63-5.mol
- MSDS FileSDS
Chemical Properties
| storage temp. | Store at RT |
Piribedil hydrochloride Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Tocris 1031 | 10 | $145 | Piribedildihydrochloride ≥99%(HPLC) |
Buy |
| Tocris 1031 | 50 | $609 | Piribedildihydrochloride ≥99%(HPLC) |
Buy |
| TRC P508753 | 10mg | $100 | PiribedilDihydrochloride |
Buy |
| Usbiological 256263 | 10mg | $389 | Piribedil dihydrochloride |
Buy |
| American Custom Chemicals Corporation API0003874 | 10MG | $255.15 | PIRIBEDIL HYDROCHLORIDE 95.00% |
Buy |
Piribedil hydrochloride Chemical Properties,Usage,Production
Uses
Piribedil dihydrochloride is a useful dopaminergic for biological research purposes.Biological Activity
A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D 3 subtype, for which it has 20 times higher affinity than for D 2 , and possesses no significant affinity for D 1 receptors.in vivo
Piribedil hydrochloride (intraperitoneal injection, 5, 15, 40 mg/kg ) alleviates the L-DOPA-induced dyskinesias in rats model of Parkinson’s disease[2].
Piribedil hydrochloride (oral gavage, 4-5 mg/kg, daily for 2 weeks) increases locomotor activity and reversal of motor deficits in adult common marmosets[3].
Piribedil hydrochloride (oral gavage, 150 mg/kg, daily for 21 days) inhibits MLL-r tumor growth and decreases the expression of MLL1 target genes in MV4;11 tumor xenografts[4].
| Animal Model: | Rat model of Parkinson’s disease[2] |
| Dosage: | 5, 15, 40 mg/kg |
| Administration: | Intraperitoneal injection, administered 5 min before administration of L-DOPA. |
| Result: | Reduced turning behaviour and AD (axial dystonia), OD (orolingual dyskinesia) and FD (forelimb dyskinesia) at 5 and 40 mg/kg. Increased LD (locomotive dyskinesias) at the 40 mg/kg. |
| Animal Model: | Adult common marmosets[3] |
| Dosage: | 4-5 mg/kg |
| Administration: | Oral gavage, daily for 2 weeks |
| Result: | Increased vigilance and alertness and reversed the downregulation of preprotachykinin mRNA induced by MPTP in rostral and caudal striatum. |
IC 50
D2 Receptor; D3 ReceptorPreparation Products And Raw materials
Piribedil hydrochloride Suppliers
Global(23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 | |
| 18930552037 | 3bsc@sina.com | China | 15813 | 69 | |
| 010-56205725 | waley188@sohu.com | China | 12323 | 58 | |
| 888-539-0666 | info@emmx.com | United States | 8435 | 60 | |
| 571-89925085 | sales@amadischem.com | China | 131885 | 58 | |
| +86-29-89586680 +86-15129568250 |
1059@dideu.com | China | 29089 | 58 | |
| 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44871 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 15921286451; 15921286451 |
2010681527@qq.com | China | 4918 | 58 | |
| +86-88938639 +86-17705817739 |
info@dycnchem.com | China | 53586 | 58 |
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