Description
1-Palmitoyl-2-arachidonoyl-
sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the
sn-1 and
sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized
in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.
Uses
1-Palmitoyl-2-arachidoyllecithin, is a phospholipid, that can be used for the studies, and elevation of autoantibodies against oxidized palmitoyl arachidonoyl phosphocholine in patients with hypertension and myocardial infarction.
Uses
16:0-20:4 PC is suitable for use:
- in the preparation of auto-oxidised phospholipid for electrospray ionisation mass spectroscopic (ESI-MS) analysis
- in liposome preparation for the treatment of organoid
- as antigen in enzyme linked immunosorbent assay (ELISA) for the detection of autoantibodies to phospholipids
General Description
Phosphatidylcholine (PC) is one of the major glycerophospholipids of the eukaryotic membranes. PC is zwitterionic. PC is synthesized via two pathways in higher eukaryotes like the triple methylation of phosphatidylethanolamine and the cytidine diphosphate (CDP)-choline pathway.
Biochem/physiol Actions
Phosphatidylcholine (PC) is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol. PC is the dominant phospholipid present in cancer and neo-neoplastic tissues. Level of 16:0-20:4 PC is less in multiple myeloma cells than in normal plasma cells.
