Uses
CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake.
Controlled substance (stimulant)
Definition
ChEBI: A 1-phenylpropan-2-amine that has S configuration.
brand name
Dexampex (Teva); Dexedrine (GlaxoSmithKline); Dextrostat (Shire); Ferndex (Ferndale);Adiparthrol;Afatin;Amfe-dyn;Amphaetex;Bipheramine;Curban;D-amfetasul;Dexadrine;Dexamed;Dexedrina;Dexten;Dextro-profetamine;Drinamyl;Durophet-m;Maxiton;Mephadexamine-r;Mephadexamin-r;Obetrol;Obotan;Proptan;Robese;Simpamina d;Steladex;Stil-2;Synatan.
World Health Organization (WHO)
Schedule II of the 1971 Convention on Psychotropic Substances. See WHO
comment for amfetamine.
(Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II),
, , 1971)
Safety Profile
Poison by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. Experimental
reproductive effects. Chronic exposure
causes central nervous system damage and
blood-pressure effects. When heated to
decomposition it emits toxic NOx. See other
amphetamine entries.
Synthesis
The compound can be prepared by optical
resolution of amphetamineor directly
from (-)-norephedrine by conversion to
the (+)-chloroamine followed by catalytic hydrogenation .
