Chemical Properties
Red-Orange Solid
Uses
A thiol specific spin label.
Uses
4-Maleimido-TEMPO (4-Maleimido-2,2,6,6,-tetramethylpiperidinooxyl) was employed as spin label to investigate the influence of bile salts on the intact rat mitochondrial membranes by electron paramagnetic resonance spectroscopy (EPR). It may be employed as spin label for the labeling of erythrocyte membranes to investigate the interaction of quercetin with erythrocyte proteins by EPR spectra.
Definition
ChEBI: 4-maleimido-TEMPO is a member of the class of piperidines that is TEMPO carrying a maleimido group at position 4. It has a role as a radical scavenger and a spin label. It is a member of aminoxyls, a member of piperidines, a member of maleimides and a dicarboximide. It is functionally related to a TEMPO.
General Description
4-Maleimido-TEMPO, a water-soluble nitroxide radical, is commonly employed as spin probe. It has been reported to inhibit the survival of CHO cells at 1mM concentrations. It is widely employed maleimide spin label for EPR studies.
Biochem/physiol Actions
Spin label used to study fluidity of brain synaptosomal membranes, internal microviscosity of erythrocytes, and human high density lipoproteins.
